Associations between sleep quality and biomarkers for neurodegeneration - A longitudinal one-year case-control study of patients with bipolar disorder and healthy control individuals

Disturbed sleep during affective episodes may impact levels of cerebrospinal fluid (CSF)-amyloid-beta (Aβ)42 and other biomarkers neurodegeneration in patients with bipolar disorder (BD). The study aimed to investigate the correlations between for Alzheimer's disease (AD) BD healthy controls (HC). We present a prospective, longitudinal case-control euthymic (N = 86) HC 44). All participants were evaluated clinical assessments at baseline, after year. patients’ states recorded weekly as euthymic, subthreshold level, major depression, or (hypo)mania. Patients re-assessed an episode if it occurred follow-up. Total scores based on three Hamilton-17 Depression Scale items analyzed relation concentrations CSF-Aβ42, CSF-Aβ40, CSF-Aβ38, CSF-Aβ42/40 42/38 ratios, CSF-soluble amyloid-precursor proteins α+β, plasma-Aβ42, plasma-Aβ40, CSF-phosphorylated-tau, CSF-total-tau, plasma-total-tau, CSF-neurofilament-light, plasma-neurofilament-light, CSF-neurogranin, serum-S100B, CSF-8-oxo-7,8-dihydro-guanosine, CSF-8-oxo-7,8-dihydro-2′-deoxyguanosine, urine-8-oxo-7,8-dihydro-guanosine, urine-8-oxo-7,8-dihydro-2′-deoxyguanosine. primary outcome was association total CSF-Aβ42 baseline follow-up estimated by regression coefficient linear mixed model. found no statistically significant associations (−2.307 pg/ml (95% CI: -9.525–4.911; p 0.523)) any biomarkers. However, higher appeared be associated CSF-Aβ42/38 lower CSF-total-tau concentration, but not correction multiple testing. In conclusion attenuated changes AD BD, larger prospective studies are needed. • Disrupted mechanism underlying AD. decrease glymphatic clearance, increase Aβ brain. investigated CSF-Aβ42. neurodegeneration. Attenuated did affect Sleep CSF Aβ42/40/38 ratios tau uncorrected analyses.